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Krakauer, M

Doseranging evidence is required because the currently available randomized trial used only 2.55 mg weekly and does not establish outcomes at higher tolerated doses

Spicy meals, creamy sauces and fried foods are common triggers

Insulin secretion and beta cell preservation Many in vitro and preclinical studies have examined agents that enhance insulin secretion, including agents that generate ATP, inhibit K + -ATP channels, raise cytosolic calcium, activate muscarinic or imidazoline receptors, suppress 2-adrenergic receptors, inhibit phosphodiesterases to increase cAMP, stimulate phospholipases or modulate various intracellular regulators of insulin exocytosis

In addition, those using a GLP-1 RA had a 16% lower MACE risk than those who did not use a GLP-1