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This receptor activation is the foundation for all downstream metabolic and physiological effects

Musculoskeletal factors unrelated to medication: Type 2 diabetes itself is associated with increased prevalence of musculoskeletal conditions, including back pain, due to factors such as diabetic neuropathy, reduced physical activity, obesity, and inflammatory processes

Activation of these receptors by GLP-1R agonists has been shown to confer protection against microvascular damage, particularly in models of diabetic retinopathy and stroke

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Thats why early research shows the highest weight-loss potential with retatrutide