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Two of Novo Nordisks key products are injectable drugs Ozempic and Wegovy, comprising the same active ingredient, semaglutide, in different doses

N Engl J Med 2020;383:1436-46.ArticlePubMed 48

FDA was notified by Novo Nordisk on Nov

Despite the significant potential and advantages of GLP-1RAs, they are inevitably accompanied by a range of possible adverse drug reactions (ADRs), as is the case with any medication

STEP 1 (Wilding et al., 2021, New England Journal of Medicine) enrolled 1,961 participants and demonstrated a mean body weight reduction of 14.9% at 68 weeks with 2.4mg subcutaneous semaglutide, the first pharmacological intervention to produce weight loss of this magnitude in a Phase 3 trial, establishing a new efficacy benchmark that became the comparison standard for all subsequent metabolic compounds including Tirzepatide and Retatrutide