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Long-term clinical trials demonstrated modest but statistically significant reductions in HbA1c of 0.3-0.68% when pramlintide was added to optimized insulin therapy, confirming sustained improvement in overall glycemic control

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Ketone Production: During rapid weight loss or low-calorie intake, the body produces ketones

Vigorous shaking degrades the peptide

The Control group and Model group were given distilled water by gavage, while the Low group and High group were given 150 mg/kg and 300 mg/kg berberine by gavage respectively