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Mechanism of Action May support insulin production by stimulating pancreatic beta-cell activity Helps slow gastric emptying, promoting a longer feeling of fullness Assists in appetite regulation and may reduce food cravings Both tirzepatide and semaglutide belong to the GLP-1 medication class, though tirzepatide also acts on the GIP receptor

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As estrogen acts to increase production of prostacyclin, it is possible that the effect of hormone replacement therapy on the heart is counteracted by these NSAIDs

In the first trial, researchers studied the effect of a 7.2mg dose of semaglutide in adults with obesity
