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This requirement of ECL1 recognition drives the above six key positions in dual or triple agonists (tirzepatide, peptide 20 (MAR423), and retatrutide) to use amino acids similar to those in GLP-1/GCG, while the other positions in the middle region show considerable variability (Fig

Neurogenesis, synaptic plasticity, and metabolic support GLP-1R stimulation promotes hippocampal neurogenesis and enhances synaptic plasticity, partly through brain-derived neurotrophic factor and modulation of glutamatergic signalling

In a review of clinical trials, the combination of combined oral contraceptive pills (COCPs) with either a GLP-1RA or tirzepatide (GLP-1 and Glucose-dependent insulinotropic polypeptide (GIP) receptors agonist) did not affect the efficacy of contraceptive drugs, even though GLP-1RAs can decrease the absorption of the concomitantly administered drug through their gastric delaying effect

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