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2021;911 doi: 10.1016/j.ejphar.2021.174482

Insulin resistance promotes Parkinsons disease through aberrant expression of alfa-Synuclein, mitochondrial dysfunction, and deregulation of the polo-like kinase 2 signaling

These findings provide crucial quantitative data for evaluating new drugs

Some anti-inflammatory effects appear independent of weight loss, which is why microdosing is being explored for RA patients who aren't significantly overweight but have signs of metabolic inflammation