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Semaglutide showed CV benefits in PIONEER-6 and SUSTAIN-6, which are consistent with other CVOTs studying GLP-1 RAs, such as EXSCEL, HARMONY, LEADER, REWIND and ELIXA, which included patients on exenatide, albiglutide, liraglutide, dulaglutide and lixisenatide, respectively [41, 42]

For example, individuals focusing on maintaining muscle during weight loss may benefit from staying toward the higher end of this range

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