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Endokrynol Pol 73(3):627643

While semaglutide is not listed as causing ED in FDA prescribing information, patients and clinicians seek clarity on this relationship

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Saini notes that GLP-1 medications have several mechanisms of action, some of which are still being unraveled in terms of how they help with weight management

Other clinically developed small-molecule GcgR antagonists include PF-06291874, LY2409021, and LGD-6972 (RVT-1502), all of which have advanced to clinical trials but ultimately were not pursued further for the treatment of T2D or obesity due to the associated increases in circulating LDL-C, body weight, hepatic fat, and blood pressure [31]
