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doi:10.1007/s00125-010-1937-z Lauffer L, Grieco A, Iakoubov R, Brubaker PL (2009) Metformin activates the AMPK pathway and improves survival of murine and human L-cells but does not directly increase GLP-1 secretion

Think Long-Term: Plan Ahead Check Your Progress Every 3-6 months, look at your: Weight Cravings Side effects Mood and energy Slowly Lower the Dose (If Ready) If you and your doctor decide to stop the medicine, reduce it gradually

doi: 10.1111/j.1463-1326.2012.01567.x

The BUD is the date after which the medication should not be used because its stability or sterility can no longer be guaranteed

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