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They both work in a similar way, but tirzepatide (Mounjaro) also mimics a second hormone, known as glucose-dependent insulinotropic polypeptide (GIP)

Multiple groups describe diabetic patients with lower plasmatic GLP-1 but heightened GIP levels and -cell resistance to the stimulatory effect of both GLP-1 and GIP (18, 149153,)

p -values less than 0.05 were considered statistically significant

Potential Side Effects and Safety Considerations GLP-1 medications can cause side effects, and they are not appropriate for everyone

Patients using tirzepatide tend to achieve greater weight loss on average, which may translate to more significant improvements in the metabolic contributors to fatigue