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GLP-1 receptor agonist Targets appetite and glucose regulation at the neurological level

After 72 weeks, participants on Zepbound lost an average of 20.2% of their body weight (averaging 50 pounds), compared to 13.7% (around 33 pounds) for those on the 2.4 mg dose of Wegovy (later studies of the 7.2 mg dose of Wegovy have showed 18.7% weight loss)

Hypertension mainly leads to heart failure with preserved ejection fraction (HFpEF)

Preclinical studies have shown that GLP-1RAs influence essential signaling pathways, including the activation of farnesoid X receptor (FXR) and liver X receptor (LXR), which are crucial in lipid metabolism and inflammation (Ibrahim et al., 2024