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[49] observed significant reduction in hs-CRP with twice-daily exenatide, and DURATION-2, DURATION-3, DURATION-3 extension, and DURATION-5 studies observed considerable reductions in inflammatory markers such as hs-CRP or CRP (Table 2) [484950515253545556575859606162636465666768697071727374757677787980818283848586]

CagriSema also shows competitive results at 22-25%, with FDA approval pending

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis was published in The BMJ in January 2024

Val8-GLP-1 also protected against A 1-40 -induced impairment of learning and memory, and reduced total tau expression and hyperphosphorylated tau levels (149, 217)

In the interim, continued shared decision making with patients and clinical vigilance for pancreatic diseases in patients on GLP-1RA therapy remains prudent