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GLP-1 medications also carry an FDA black box warning for risk of thyroid C-cell tumors, and should not be used by patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN2)

In murine pancreatic Min6-K8 cells, prevention of cytosolic glutamate production by KO of a key component of the malate-aspartate shuttle or triple KO of the vesicular glutamate transporters Slc17a6, Slc17a7, and Slc17a8 impaired GLP-1-induced insulin secretion [515]
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J Clin Endocrinol Metab (2009) 94:3944

In accordance with the TITAN Guidelines 2025 for ethical use of Artificial Intelligence (AI) in healthcare research, we ensure transparency in methodology and reporting [9]
