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Insights from real-world clinical data paint a picture of who responds and who does not to GLP-1s outside of clinical trials.

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Approval based on results from the STEP clinical trial where Wegovy demonstrated (unprecedented efficacy/weight reduction) (OR) statistically significant weight

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However, very recently, on February 13, 2020, the US Food and Drug Administration (FDA) ordered the withdrawal of lorcaserin from markets, as a clinical trial to assess drug safety showed an increased risk of cancer