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Hair follicles are metabolically active and depend on amino acids, iron, zinc, B vitamins, and vitamin D to function properly
Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC
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