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Furthermore, post hoc subgroup analyses of cardiovascular outcome trials have suggested a greater cardiorenal protection in patients treated with a combination versus either monotherapy

Since tirzepatide is a dual GLP1R/GIPR agonist, the interpretation is compelling: GIP receptor activation normally buffers the nausea-inducing effects of GLP-1 agonism, and when that buffer is genetically impaired, the GLP-1 component goes unchecked