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Its use outside of formally approved clinical trials is not sanctioned
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References Stone GW, Lindenfeld J, Abraham WT, Kar S, Lim DS, Mishell JM, Whisenant B, Grayburn PA, Rinaldi M, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Marx SO, Cohen DJ, Weissman NJ, Mack MJ
doi:10.1097/00000542-198104000-00013 Singh G, Krauthamer M, Bjalme-Evans M