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Instead of relying primarily on historical relationships, many sponsors are exploring more data-driven approaches to site selection, including: regional disease heatmaps investigator performance analytics patient population modeling AI-assisted feasibility analysis These approaches aim to answer a fundamental question: Which sites can actually recruit the patients required for modern metabolic trials

The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses

MEDI0382, a GLP1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: A randomised, controlled, doubleblind, ascending dose and phase 2a study

Clinical practice guideline on pharmacological interventions for adults with obesity