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This suggests that NAD+ repletion can have metabolic benefits in humans, though the magnitude depends on baseline NAD+ status and the specific precursor used

in reality, the medication creates a metabolic advantage of roughly 1,200-1,500 calorie deficit per week when combined with reasonable eating and movement habits

Avoid relying on stimulant laxatives (senna, bisacodyl) for regular use, as these can create dependency

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