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doi:10.1016/j.molmet.2020.101102 34

Despite the observational nature of this pharmacovigilance study and the inherent limitations of the FAERS database, our preliminary findings in this work could provide a better basis for understanding the potential psychiatric AEs that may occur with GLP-1 RA treatment, assisting clinicians to focus on these AEs and provide early intervention for optimal risk management

Byetta is indicated as an adjunct to diet and exercise in adults with T2DM and is dosed twice daily via SC injection

Researchers who jump to high doses quickly experience more pronounced cardiovascular effects because the glucagon receptor gets activated intensely before the body can adapt

Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion
