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You start with a 2.5-milligram dose and increase to 5 milligrams after a month

This supports optimal nutritional practices that enhance your medications efficacy and minimize gastrointestinal side effects

Avoid the rebound swing Moving directly from a hard cut into uncontrolled eating can erase progress quickly and worsen the relationship with food

Database Characteristics We utilized the TriNetX database (US Collaborative Network), which includes de-identified electronic medical records from 67 healthcare organizations (HCO)

This guide covers how semaglutide dosing for weight loss works from the first injection through the maintenance phase, including the 2026 dosing changes, a unit-based chart for compounded versions, and the clinical reasoning behind why doses increase gradually over time