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Yes, GLP-1 medications (semaglutide and tirzepatide) have been proven safe for long-term use in clinical trials lasting up to 2+ years

Studies show an average weight loss of 15% over 68 weeks

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The foundation should be a calorie-controlled diet that creates a sustainable deficittypically 500600 kcal below maintenance requirementswhilst ensuring sufficient intake of macronutrients and micronutrients

Orlistat (Xenical / Alli): The Fat Stopper Orlistat works differently from GLP-1 medications