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KDOQI (Kidney Disease Outcomes Quality Initiative) clinical practice guideline for diabetes and CKD: 2012 update

[1] [17] Practical strategies for managing common side effects include: Eat smaller, more frequent meals : Rather than three large meals, consume 46 smaller portions throughout the day to avoid overwhelming your slowed digestive system Choose easily digestible foods : Lean proteins, cooked vegetables, and simple carbohydrates are generally better tolerated than high-fat, fried, or heavily spiced foods Stay well-hydrated : Adequate fluid intake helps prevent constipation and may reduce nausea

In RANDs 2025 survey of users, ~52% reported nausea and ~34% diarrhea (mostly mild), and ~20% reported vomiting

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