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IGF-1 suppressed NF-B signalling by upregulating miR-219a-2-3p and inhibiting YY1 gene expression, which is important for the activation of NF-B signalling [89]

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The Retarutide obtained by these methods is similar or similar in structure and biological activity to the Retarutide synthesized by chemical methods, but has the advantages of higher yield and easier preparation
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