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Chin J Hyperten 2017

Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling

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However, women experiencing severe nausea, vomiting, or acute GI symptoms during tirzepatide initiation should discuss backup contraception methods with their provider, as pill efficacy may be temporarily compromised during periods of GI upset

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