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Use separate injection sites, at least 2 inches apart, typically alternating sides of the abdomen or using one abdominal site and one thigh site

Contraindications for non-diabetic GLP-1 use include pregnancy, personal history of thyroid cancer, and certain gastrointestinal disorders

Literature data shows that optimized tri-agonists normalize body weight in diet-induced obesity (DIO) in mice and increase energy expenditure more effectively than GLP1R mono-agonists or GLP1R/GIPR (Gastric inhibitory polypeptide receptor) co-agonists 9

Role of GLP-2 in inflammatory regulation in IBD Administration of teduglutide, a GLP-2 analog to mice with DSS-induced colitis, resulted in a significantly greater small bowel and colon weight and length compared with untreated mice