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Description
They work by blocking enzymes that produce prostaglandins

Triglycerides and LDL cholesterol levels went down, and HDL cholesterol levels went up a little
Estradiol improves also insulin-induced glucose uptake and GLUT4 translocation to the plasma membrane in adipocytes (73)

Remarkably, renal improvement has been obtained without major changes in insulin secretion or glucose tolerance, thus supporting direct renal effects

Focusing on its safety makes these findings even clearer
