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The 104-Week Extension: Weight Loss Doesn't Stop at 80 Weeks TRIUMPH-1 included a prespecified 104-week extension in patients with BMI 35
Exendin-4 could still exhibit stimulatory activity in the same setting, suggesting that either mTORC2 alone or both mTOR complexes must be blocked in order to completely abrogate GLP-1R signalling action on glycolysis
Second, there was moderate to high heterogeneity in some of the outcomes analyzed
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Factors like diet, activity level, and dosage adjustments can impact your results
