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The placebo group gained back nearly 21 pounds while the orforglipron group stayed essentially flat

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Reports vary considerably and include: Reduced emotional eating or changes in food-related reward responses Altered mood states, including feelings of flatness or reduced enthusiasm Changes in social behaviour or interest in activities previously enjoyed Shifts in anxiety levels or emotional reactivity It is important to emphasise that there is currently no established causal link between semaglutide and personality changes

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