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GLP-1 (Glucagon-Like Peptide-1) Delayed gastric emptying (lowers appetite and promotes extended satiation) Increased secretion of insulin Lowered glucose levels GIP (Glucose-dependent Insulinotropic Polypeptide) Increased uptake and storage of glucose Elevated fatty acid uptake Increased secretion of insulin GCG (Glucagon) Elevated lipolysis and energy expenditure Increased secretion of insulin Promotion of satiety (feeling full) Prior work on developing triple receptor agonist molecules shows a synergistic effect between GLP-1, GIP and GCG when said molecule is optimized to adequately target their respective receptors

[7] [8] This is largely attributed to sustained weight loss, improvements in insulin sensitivity, reduced systemic inflammation, and favourable hormonal changes

This can lead to fewer cravings, smaller meal portions, less food noise or preoccupation with food in your head, better insulin sensitivity, and improved gut health

The risk may be greater for those using the drugs at higher doses or for longer stretches of time

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