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Express Scripts has been an aggressive adopter of biosimilar preferred tier placement, excluding reference biologics in categories where biosimilars have achieved FDA interchangeability designation
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Nevertheless, concerning case reports and retrospective studies have emerged in 2023 of undigested gastric contents in sedated/anaesthetised patients undergoing elective endoscopy with unprotected airways: Klein and Hobai (2023) published a case report of a patient taking semaglutide for weight loss who experienced pulmonary aspiration from undigested food content identified during routine gastroscopy, despite fasting 18hr prior to the procedure

Updated mechanisms of MASLD pathogenesis