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Identify outliers (suspiciously cheap suggesting poor quality or too expensive without justifying quality difference)

Avoid rich, fatty, or heavily spiced foods, which can exacerbate nausea

The Phase 2 retatrutide trial in obesity (Jastreboff et al., NEJM 2023) hit 24.2% at 48 weeks
19 Furthermore, magnesium trisilicate (found in some Gaviscon preparations) may cause fetal nephrolithiasis, hypotonia, respiratory distress, and cardiovascular impairment if used long-term and at high doses

Orekhov, Tannaz Jamialahmadi, Amirhossein Sahebkar Current Medicinal Chemistry.2025
