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As an NAD+ precursor, niacinamide supports the function of sirtuins, enzymes involved in metabolic regulation, inflammation control, and longevity pathways

Tirzepatide: The New Contender Tirzepatide is a newer medication that acts on both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, making it a dual agonist

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Tirzepatide with B12 is popular because GLP-1 medications can sometimes reduce absorption of certain vitamins, and B12 deficiency is associated with fatigue, a side effect some tirzepatide users report

Tirzepatide works as a dual agonist, targeting two key receptors involved in appetite regulation and metabolic processes in GLP-1 and GIP