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Active GLP-1 then flows to peripheral organs where it stimulates the incretin effect 1,2,10

[4] Longer courses of antifungal therapy or suppressive maintenance regimens (such as fluconazole 150 mg weekly for 6 months) may be appropriate under specialist guidance from a GP or sexual health service

It is important to note that these values are based on the human GIPR (hGIPR), while tirzepatide is much less potent (30100-fold reduced) at the mouse GIPR (mGIPR) 45

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In short, it depends on many factors, including starting weight, approach, and whether youre using a medically supervised program