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Transdermal semaglutide administration in mice: Reduces body weight by suppressing appetite and enhancing metabolic rate

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Ex-4 significantly reduces neuroinflammation by converting proinflammatory M1 microglia into anti-inflammatory M2 microglia both in vitro and in vivo through the rescue of the expression of Arf and Rho GAP adapter protein 3 (ARAP3)

It isn't approved for treating obesity, but during tirzepatide diabetes trials, researchers noted people who got tirzepatide lost much more weight than those on standard diabetes therapy