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Another plausible mechanistic explanation for a diminished incretin effect is the TCF7L2 -dependent repression of GLP-1R and GIPR expression on the -cells [569]

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doi:10.1210/er.2015-1084 9

This phenomenon is thought to result from compensatory mechanisms, such as increased SGLT1 activity and upregulation of SGLT2 expression

P = 0.12)
