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Since muscle is a major energy utilizer 17,41 , minimizing muscle mass during caloric restriction can substantially reduce energy expenditure, thus sparing energy for the maintenance of other more critical organ systems 42,43,44

Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

This makes them an excellent option for those dealing with age-related metabolic slowdown

doi: 10.2165/11591400-000000000-00000

A wellness stipend uses the same reimbursement model as an LSA but is limited to wellness-related expenses