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It's what happens when weight loss outpaces support

Metformin is now increasingly being used in combination with new incretin-based therapies: glucagon-like peptide 1 (GLP-1) analogues and dipeptidyl peptidase-4 (DPP-4) inhibitors [46], both of which enhance pancreatic beta cell function

While muscle loss is standard with any diet or weight-loss regimen, loss of muscle on GLP-1s can be more dramatic, Ahmed says, causing what's been dubbed "Ozempic face," a bonier, looser-skinned look, where the muscle loss is particularly noticeable

This allows them to refine their strategy to retain current customers and identify potential new customers where theyre most engaged

10.3390/toxics13070594 14 EngstrmA.WintzellV.MelbyeM.SvanstrmH.EliassonB.GudbjrnsdottirS.et al (2024)