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Our studies revealed key signaling mechanisms underlying the role of GPR17 in regulating GLP-1 secretion and suggest future opportunities for pharmacologically targeting GPR17 with inverse agonists to maximize GLP-1 secretion ![Graphical Abstract][1] Graphical Abstract ### Competing Interest Statement The authors have declared no competing interest

Compounded semaglutide stability depends on formulation type, storage temperature, and container integrity
Typical Research Dosing Protocol

A new Phase 2 trial at Johns Hopkins testing the GLP-1 drug pegsebrenatide in progressive MS may finally explain why adults on diabetes medications for a decade show measurably slower brain shrinkage

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