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Each episode of lupus nephritis causes irreversible kidney injury, initiating and, subsequently, exacerbating chronic kidney disease
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Formation of bilirubin Occurs in the reticuloendothelial system (spleen, liver, bone marrow): * RBC breakdown haemoglobin * Haem biliverdin * Biliverdin bilirubin (unconjugated) This initial form is fat-soluble and toxic if accumulated 2

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