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Obesity, a chronic disease, puts people at risk for heart disease, diabetes, breathing problems, stroke and some cancers, according to the Centers for Disease Control and Prevention

doi: 10.1093/brain/awad064

Within the pancreas, GIP and GLP-1 together promote cell proliferation and inhibit apoptosis, thereby expanding pancreatic cell mass, while GIP enhances postprandial glucagon response and GLP-1 suppresses it

The neuronal mitochondrial dysfunction that follows a drop in estradiol levels in women causes insulin insensitivity and eventually brain insulin resistance to develop (16, 213, 214)