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Semaglutide may slightly influence vitamin B12 absorption in some people, but adding B12 is still more of a wellness approach than a proven scientific strategy

The slightly greater improvements in our study compared to past studies is likely explained by several program features: patients could titrate or switch between GLP-1 RAs based on clinical response, most participants did not have diabetes (a group that tends to experience greater weight change with GLP-1 RAs) [25], and the behavioral coaching delivered in this hybrid model is more intensive than the lighter-touch educational or lifestyle support typically offered in clinical or real-world studies, which may enhance medication effects

Ozempic is a medication used to help manage blood sugar levels in people with type 2 diabetes

Setmelanotide targets specific genetic mutations that can lead to severe obesity, helping to regulate hunger and body weight

Overweight and obesity management (NG246) full guideline PDF NICE