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The pharmacology of drugs such as Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin receptor agonists is mainly characterized by two mechanisms of action

Identifying predictors of response could guide treatment selection and improve population-level outcomes by reducing trial-and-error prescribing

Studies showed that GLP-1 receptor agonists like semaglutide are associated with a high proportion of lean muscle loss, which can range from 25% to 40% of the total weight reduction in patients with obesity

doi: 10.1007/s10620-020-06106-8 60 YangC-JChangH-CSungP-CGeM-CTangH-YChengM-Let al

Cognition improved in exenatide treated patients in fluid intelligence (baseline 38.4 (8.2), 12 weeks 52.9 (6.6), p = 0.0005), processing speed (baseline 43.7 (9.4), 12 weeks 58.4 (10.4), p = 0.0058) and episodic memory (baseline 49.4 (5.3), 12 weeks 62.1 (13.2), p = 0.0315)