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The condition is sometimes linked to obesity or diabetes, which are issues patients may treat with GLP-1s

A significant challenge in interpreting the data arose from the heterogeneity in the GLP-1RA doses administered and the variable reporting of these doses

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In the GLP-1RA versus SGLT-2i comparison ( n = 82,789 pairs), the hazard ratios for composite outcomes suggested a smaller but still significant increase in risk for the GLP-1RA group (HR ranging from 1.188 to 1.231)

GLP-1RAs attenuate systemic and local inflammation by inhibiting the p38 MAPK/NF-B pathway, reducing cytokine production, endothelial injury, and microvascular thrombosis