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Data availability All data generated or analyzed during this study are included in this published article

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Liraglutide enters the brain in a GLP-1R-dependent manner, and a fluorescent version of liraglutide was observed in the hypothalamus (ARC, paraventricular nucleus (PVN), supraoptic NTS, supraoptic decussation) and several circumventricular organs (CVOs, e.g., median eminence (ME), area postrema (AP), subfornical organ, and organum vasculosum of lamina terminalis)