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JAMA Psychiatry Editor in Chief Dost ngr, MD, PhD, explains why his 2025 pick for Editors Choice: Clinical Trials of the Year is a randomized clinical trial showing that semaglutide is safe and effective in patients with schizophrenia who also experience overweight or #obesity and #prediabetes

Mounjaro does all that plus activates GIP receptors, potentially enhancing metabolic effects beyond GLP-1 alone

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identify GLP-1 receptor agonists mitigating Alzheimers disease-related cognitive decline and amyloid pathology in a transgenic mouse model via promoting phagocytosis and through activation of the CaMKK2AMPK signaling pathway.

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