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A single composition-of-matter patent covering a novel active pharmaceutical ingredient can underpin billions in annual revenue, drive the entirety of a companys enterprise value, and define whether an acquisition makes rational economic sense or destroys capital

60 In a meta-analysis by Shi et al., GLP-1RAs significantly reduced AF events compared to metformin, sulfonylurea, insulin and non-sulfonylurea in patients with T2D and were associated with better outcomes compared to other medications

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Abnormal cardiac energy metabolism In the state of diabetes, the hearts metabolic processes experience substantial alterations because of a changed metabolic environment marked by hyperglycemia, hyperlipidemia, and insulin resistance (51)