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In CVOTs, liraglutide, semaglutide and dulaglutide demonstrated appreciable cardiovascular and renal protective effects, among which liraglutide had an appreciable effect on mitigating the risk of cardiovascular death [4], while semaglutide and dulaglutide conferred a risk reduction on non-fatal stroke [22, 23]

However, GLP-1RAs are usually modified analogues that are designed to be much longer acting, with a therapeutic window of up to 1 week, and their use is rapidly becoming a key treatment for patients with type 2 diabetes as well as those with a requirement for weight loss

For most manufacturers, that means SPPSand the chemicals involvedwill remain a reality, at least in the near term

Of these, GLP-1 RAs are generally preferred because of their demonstrated cardiovascular benefits and potential for improved renal outcomes [2]

Two months later, Novo Nordisk terminated the partnership because Hims continued to sell its own compounded GLP-1 drugs alongside Wegovy