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In addition to directly influencing satiety and appetite control via hypothalamic and hindbrain pathways, GLP-1RAs appear to engage higher-order networks involved in reward processing and emotional regulation, such as the insula, amygdala, and medial prefrontal cortex

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Acta Neurol Scand 2010

While GLP-1 medications appear equally effective for weight loss in both perimenopausal and postmenopausal individuals, they are not without side effects, such as digestive upset and muscle loss

These medications have three main actions